広島大学 医系科学研究科 神経生理学教室
Department of Neurophysiology
Graduate School of Biomedical & Health Sciences
Hiroshima University
原著論文
2021
Hashimoto K, Yamawaki Y, Yamaoka K, Yoshida T, Okada K, Tan W, Yamasaki M, Matsumoto-Makidono Y, Kubo R, Nakayama H, Kataoka T, Kanematsu T, Watanabe M, Okamoto Y, Morinobu S, Aizawa H, Yamawaki S.
Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine. Brain Commun. 3(4):fcab285. (2021) doi: 10.1093/braincomms/fcab285.
Lai ESK, Nakayama H, Miyazaki T, Nakazawa T, Tabuchi K, Hashimoto K, Watanabe M, Kano M.
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum. Front Neural Circuits. 28;15:676891. (2021) doi: 10.3389/fncir.2021.676891.
Okada K, Nishizawa K, Kobayashi T, Sakata S, Hashimoto K, Kobayashi K.
Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory. Sci Rep. 11(1):13589. (2021) doi: 10.1038/s41598-021-93045-7.
Matsuoka T, Yamasaki M, Abe M, Matsuda Y, Morino H, Kawakami H, Sakimura K, Watanabe
M, Hashimoto K.
Kv11 (ether-a-go-go-related gene) voltage-dependent K+ channels promote
resonance and oscillation of subthreshold membrane potentials. J Physiol. 599, 547-569 (2021) doi: 10.1113/JP280342.
2020
Takahashi T, Yoshida T, Harada K, Miyagi T, Hashimoto K, Hide I, Tanaka S, Irifune M, Sakai N.
Component of nicotine-induced intracellular calcium elevation mediated
through α3- and α5-containing nicotinic acetylcholine receptors are regulated
by cyclic AMP in SH-SY 5Y cells. PLoS One 15(11):e0242349 (2020). doi: 10.1371/journal.pone.0242349.
Hara N, Morino H, Matsuda Y, Satoh K, Hashimoto K, Maruyama H, Kawakami H.
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia. Mol Brain. 13:163 (2020). doi: 10.1186/s13041-020-00700-7.
Aikawa K, Yoshida T, Ohmura Y, Lyttle K, Yoshioka M, Morimoto Y.
Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress. Brain Res. 1746:146980 (2020). doi: 10.1016/j.brainres.2020.146980.
2019
Nakao H, Kishimoto Y, Hashimoto K, Kitamura K, Yamasaki M, Nakao K, Watanabe M, Kano M, Kirino Y, Aiba A.
mGluR1 in cerebellar Purkinje cells is essential for the formation but
not expression of associative eyeblink memory. Sci Rep 14;9(1):7353 (2019)
Sakai, Y., Kassai, H., Nakayama, H., Fukaya, M., Maeda, T., Nakao, K., Hashimoto, K., Sakagami, H., Kano, M., Aiba, A.
Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje
cells. Sci Rep 26;9(1):2799. (2019)
2018
Nakayama, H., Abe, M., Morimoto, C., Iida, T., Okabe, S., Sakimura, K., Hashimoto, K.
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nat Commun. 9:2830. doi: 10.1038/s41467-018-05100-z.(2018)
Kubo, R., Aiba, A., Hashimoto, K.
The anatomical pathway from the mesodiencephalic junction to the inferior
olive relays perioral sensory signals to the cerebellum in the mouse. J. Physiol. 596, 3775-3791 (2018)
Okada, K., Nishizawa, K., Setogawa, S., Hashimoto, K., Kobayashi, K.
Task-dependent function of striatal cholinergic interneurons in behavioural
flexibility. Eur J Neurosci. 47, 1174-1183. (2018)
2017
Miyazaki, T., Yamasaki, M., Hashimoto, K., Kohda, K., Yuzaki, M., Shimamoto, K., Tanaka, K., Kano, M., Watanabe, M..
Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. PNAS114, 7438-7443. (2017)
Nakai, N., Nagano, M., Saitow, F., Watanabe, Y., Kawamura, Y., Kawamoto, A., Tamada, K., Mizuma, H., Onoe, H., Watanabe, Y., Monai,
H., Hirase, H., Nakatani, J., Inagaki, H., Kawada, T., Miyazaki, T., Watanabe,
M., Sato, Y., Okabe, S., Kitamura, K., Kano, M., Hashimoto, K., Suzuki, H., Takumi, T.
Serotonin rebalances cortical tuning and behavior linked to autism symptoms
in 15q11-13 CNV mice. Sci Adv.3: e1603001. (2017)
2016
Narushima, M., Uchigashima, M., Yagasaki, Y., Harada, T., Nagumo, Y., Uesaka, N., Hashimoto, K., Aiba, A., Watanabe, M., Miyata, M., Kano, M.
The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent
Maintenance of Mature Synaptic Connectivity in the Visual Thalamus. Neuron91, 1097-1109 (2016)
Miyake, K., Ohta, T., Nakayama, H., Doe, N., Terao, Y., Oiki, E., Nagatomo, I., Yamashita, Y., Abe, T., Nishikura,
K., Kumanogoh, A., Hashimoto, K., Kawahara, Y.
CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Rep.17, 2004-2014 (2016)
Matsumoto-Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M.,
Kano, M., Sakimura, K., Hashimoto, K.
Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior
Olive. Cell Rep.16, 994-1004 (2016)
Ichikawa, R., Hashimoto, K., Miyazaki, T., Uchigashima, M., Yamasaki, M., Aiba, A., Kano, M., Watanabe,
M.
Territories of heterologous inputs onto Purkinje cell dendrites are segregated
by mGluR1-dependent parallel fiber synapse elimination. Proc Natl Acad Sci U S A.113, 2282-2287 (2016).
2015
Morino, H., Matsuda, Y., Muguruma, K., Miyamoto, R., Ohsawa, R., Ohtake, T., Otobe, R., Watanabe, M., Maruyama, H., Hashimoto, K., Kawakami, H.
A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. Mol Brain.8:89 (2015).
Ageta-Ishihara, N., Yamazaki, M., Konno, K., Nakayama, H., Abe, M., Hashimoto, K., Nishioka, T., Kaibuchi, K., Hattori, S., Miyakawa,
T., Tanaka, K., Huda, F., Hirai, H., Hashimoto, K., Watanabe, M., Sakimura, K., Kinoshita, M.
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate
clearance. Nat. Commun.6:10090 (2015).
Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K., Sasai, Y.
Self-organization of polarized cerebellar tissue in 3D culture of human
pluripotent stem cells. Cell Rep. 10, 537-550 (2015).
2014
Kawata, S., Miyazaki, T., Yamazaki, M., Mikuni, T., Yamasaki, M., Hashimoto, K., Watanabe, M., Sakimura, K. & Kano, M.
Global scaling down of excitatory postsynaptic responses in cerebellar
purkinje cells impairs developmental synapse elimination. Cell Rep. 8, 1119-1129 (2014).
Piochon C, Kloth AD, Grasselli G, Titley HK, Nakayama H, Hashimoto K, Wan V, Simmons DH, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe
M, Takumi T, Kano M, Wang SS, Hansel C.
Cerebellar plasticity and motor learning deficits in a copy-number variation
mouse model of autism. Nat. Commun. 5, 5586 (2014).
Ohtani, Y., Miyata, M., Hashimoto, K., Tabata, T., Kishimoto, Y., Fukaya, M., Kase, D., Kassai, H., Nakao, K., Hirata, T., Watanabe, M., Kano, M., & Aiba, A.
The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function. J. Neurosci. 34, 2702-2712 (2014).
2013
Kawamura, Y., Nakayama, H., Hashimoto, K., Sakimura, K., Kitamura, K. & Kano, M.
Spike timing-dependent selective strengthening of single climbing fiber
inputs to Purkinje cells during cerebellar development. Nat. Commun. 4, 2732 (2013)
Takeda, I., Takahashi, T., Ueno, H., Morino, H., Ochi, K., Nakamura, T., Hosomi, N., Kawakami, H., Hashimoto, K., Matsumoto M.
Autosomal recessive Andersen?Tawil syndrome with a novel mutation L94P
in Kir2.1. , Neurology and Clinical Neuroscience 1 (2013)
2012
Uesaka, N., Mikuni, T., Hashimoto, K., Hirai, H., Sakimura, K. & Kano, M.
Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain. J. Neurosci. 32, 11657-11670 (2012)
Tanimura, A., Uchigashima, M., Yamazaki, M., Uesaka, N., Mikuni, T., Abe,
M., Hashimoto, K., Watanabe, M., Sakimura, K. & Kano, M.
Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol
after retrograde synaptic suppression. Proc. Natl. Acad. Sci. U S A. 109, 12195-12200 (2012)
Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M, Kano M. GABAergic Inhibition
Regulates Developmental Synapse Elimination in the Cerebellum. Neuron 74, 384-396 (2012)
Miyazaki T, Yamasaki M, Hashimoto K, Yamazaki M, Abe M, Usui H, Kano M, Sakimura K, Watanabe M.
Cav2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic
Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization.
J. Neurosci. 32, 1311-1328 (2012)
2011
Ichikawa, R., Yamasaki, M., Miyazaki, T., Konno, K., Hashimoto, K., Tatsumi, H., Inoue, Y., Kano, M., Watanabe, M.
Developmental switching of perisomatic innervation from climbing fibers to Basket cell fibers in cerebellar Purkinje cells. J Neurosci. 31, 16916-16927 (2011)
Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki, M., Shin, H.S., Watanabe,
M., Sakimura, K. Kano, M
Postsynaptic P/Q-type Ca2+ channels in cerebellar Purkinje cells mediate synaptic competition among
multiple climbing fiber inputs during postnatal development. Proc. Natl. Acad. Sci. USA. 108, 9987-9992 (2011)
Miyata, M., Kishimoto, Y., Tanaka, M., Hashimoto, K., Hirashima, N., Murata, Y., Kano, M., Takagishi, Y.
A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible
Mechanism Underlying Neurological Disorder in Myosin Va Disease. J Neurosci. 31, 6067-6078 (2011)
2010
Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata,
S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K. & Kano, M.
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase
α mediates retrograde suppression of synaptic transmission. Neuron 65, 320-327 (2010)
2009年（広大赴任以前）
Taniguchi, S., Nakazawa, T., Tanimura, A., Kiyama, Y., Tezuka, T., Watabe, AM., Katayama, N., Yokoyama, K., Inoue, T., Izumi-Nakaseko, H., Kakuta, S., Sudo, K., Iwakura, Y., Umemori, H., Inoue, T., Murphy, NP., Hashimoto, K., Kano, M., Manabe, T. & Yamamoto, T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J 28, 3717-3729 (2009)
Hashimoto, K., Ichikawa, R., Kitamura, K., Watanabe, M. & Kano, M. Selective translocation of the “winner” climbing fiber to Purkinje cell dendrite and subsequent elimination of the “loser” from the soma during cerebellar development. Neuron 63, 106-118 (2009).
Tanimura, A., Kawata, S., Hashimoto, K. & Kano, M. Not glutamate but
endocannabinoids mediate retrograde suppression of cerebellar parallel
fiber to Purkinje cell synaptic transmission in young adult rodents. Neuropharmacology 57, 157-163 (2009).
Ohkawa,
N., Hashimoto, K., Hino, T., Migishima, R., Yokoyama, M., Kano, M.
& Inokuchi, K. Motor discoordination of transgenic mice
overexpressing a microtubule destabilizer, stathmin, specifically in
Purkinje cells. Neurosci. Res. 59, 93-100 (2007).
Kakizawa,
S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu,
H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M.,
Watanabe, M., Iino, M. & Takeshima, H. Junctophilin-mediated
channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 26, 1924-1933 (2007).
Kina, S., Tezuka, T., Kusakawa, S., Kishimoto, Y., Kakizawa, S., Hashimoto, K., Ohsugi, M., Kiyama, Y., Horai, R., Sudo, K., Kakuta, S., Iwakura, Y., Iino, M., Kano, M., Manabe, T. and Yamamoto, T. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. Eur. J. Neurosci. 26, 2269-2278 (2007).
Takagishi, Y., Hashimoto, K., Kayahara, T., Watanabe, M., Otsuka, H., Mizoguchi, A., Kano, M. & Murata, Y. Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. 67, 909-923 (2007).
Tabata, T., Kawakami, D., Hashimoto, K., Kassai, H., Yoshida, T., Hashimotodani, Y., Fredholm, B., Sekino, Y., Aiba, A. & Kano, M. G protein-Independent Neuromodulatory Action of Adenosine on Metabotropic Glutamate Signaling in Mouse Cerebellar Purkinje Cells. J. Physiol. 581, 693-708 (2007).
Narushima, M., Uchigashima, M., Fukaya, M., Matsui, M., Manabe, T., Hashimoto,
K., Watanabe, M. & Kano, M. Tonic enhancement of endocannabinoid-mediated
retrograde suppression of inhibition by cholinergic interneuron activity
in the striatum. J. Neurosci. 27, 496-506 (2007).
Narushima, M., Uchigashima, M., Hashimoto, K., Watanabe, M. & Kano,
M. Depolarization-induced suppression of inhibition mediated by endocannabinoids
at synapses from fast-spiking interneurons to medium spiny neurons in the
striatum. Eur. J. Neurosci. 24, 2246-2252 (2006).
Yamasaki, M., Hashimoto, K. & Kano, M. Miniature synaptic events elicited
by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. J. Neurosci. 26, 86-95 (2006).
Narushima, M., Hashimoto, K. & Kano, M. Endocannabinoid-mediated short-term
suppression of excitatory synaptic transmission to medium spiny neurons
in the striatum. Neurosci. Res. 54, 159-164 (2006).
Miyazaki, T., Hashimoto, K., Uda, A., Sakagami, H., Nakamura, Y., Saito,
S. Y., Nishi, M., Kume, H., Tohgo, A., Kaneko, I., Kondo, H., Fukunaga,
K., Kano, M., Watanabe, M. & Takeshima, H. Disturbance of cerebellar
synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific
receptor-like protein family. FEBS Lett. 580, 4057-4064 (2006).
Kawamura, Y., Fukaya, M., Maejima, T., Yoshida, T., Miura, E., Watanabe,
M., Ohno-Shosaku, T., Kano, M. The CB1 cannabinoid receptor is the major
cannabinoid receptor at excitatory presynptic site in the hippocampus and
cerebellum J. Neurosci. 26, 2991-3001 (2006)
Tabata, T., Haruki, S., Nakayama, H., Kano, M. GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells. J. Physiol. 563, 443-457 (2005)
Tabata, T., Araishi, K., Hashimoto, K., Hashimotodani, Y., van der Putten,
H., Bettler, B. & Kano, M. Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate
signaling in the absence of GABA. Proc. Natl. Acad. Sci. USA 101, 16952-16957 (2004).
Sato,
M., Tabata, T., Hashimoto, K., Nakamura, K., Nakao, K., Katsuki, M.,
Kitano, J., Moriyoshi, K., Kano, M. & Nakanishi, S. Altered agonist
sensitivity and desensitization of neuronal mGluR1 responses in knock-in
mice by a single amino acid substitution at the PKC phosphorylation
site. Eur. J. Neurosci. 20, 947-955 (2004).
Miyazaki, T., Hashimoto, K（共同第一著者）., Shin, H. S., Kano, M. & Watanabe, M. P/Q-type Ca2+ channel α1A regulates synaptic competition on developing cerebellar Purkinje cells.
J. Neurosci. 24, 1734-1743
(2004).
Kitao,
Y., Hashimoto, K., Matsuyama, T., Iso, H., Tamatani, T., Hori, O.,
Stern, D. M., Kano, M., Ozawa, K. & Ogawa, S. ORP150/HSP12A
regulates Purkinje cell survival: a role for endoplasmic reticulum
stress in cerebellar development. J. Neurosci. 24, 1486-1496 (2004).
Manita, S., Kawamura, Y., Sato, K., Inoue, M., Kudo, Y., Miyakawa, H. Predominant contribution of N-type Ca2+ channels for glutamate release at rat CA3-CA1 synapses. Eur. J. Pharmacol. 499, 265-274 (2004)
Nakayama, H., Oda, Y. Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain. J. Neurosci. 24, 3199-3209 (2004)
Kawamura, Y., Manita, S., Nakamura, T., Inoue, M., Kudo, Y., Miyakawa, H. Glutamate release increases during mossy-CA3 LTP, but not during Schaffer-CA1 LTP. Eur. J. Neurosci. 19, 1591-1600 (2004)
Takeda, Y., Akasaka, K., Lee, S., Kobayashi, S., Kawano, H., Murayama,
S., Takahashi, N., Hashimoto, K., Kano, M., Asano, M., Sudo, K., Iwakura,
Y. & Watanabe, K. Impaired motor coordination in mice lacking neural
recognition molecule NB-3 of the contactin/F3 subgroup. J. Neurobiol. 56, 252-265 (2003).
Hashimoto, K. & Kano, M. Functional differentiation of multiple climbing
fiber inputs during synapse elimination in the developing cerebellum. Neuron 38, 785-796 (2003).
Kasuga, A., Enoki, R., Hashimoto, Y., Akiyama, H., Kawamura, Y., Inoue,
M., Kudo, Y., Miyakawa, H. Optical detection of dendritic spike initiation
in hippocampal CA1 pyramidal neuron. Neuroscience 118, 899-907 (2003) .
Yoshida,
T., Hashimoto, K., Zimmer, A., Maejima, T., Araishi, K. & Kano, M.
The cannabinoid CB1 receptor mediates retrograde signals for
depolarization-induced suppression of inhibition in cerebellar Purkinje
cells. J. Neurosci. 22, 1690-1697 (2002).
Watase, K., Weeber, E. J., Xu, B., Antalffy, B., Yuva-Paylor, L., Hashimoto, K., Kano, M., Atkinson, R., Sun, Y., Armstrong, D. L., Sweatt, J. D., Orr, H. T., Paylor, R. & Zoghbi, H. Y. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron 34, 905-919 (2002).
Nishi, M., Hashimoto, K., Kuriyama, K., Komazaki, S., Kano, M., Shibata,
S. & Takeshima, H. Motor discoordination in mutant mice lacking junctophilin
type 3. Biochem. Biophys. Res. Commun. 292, 318-324 (2002).
Miyata, M., Kim, H. T., Hashimoto, K., Lee,
T. K., Cho, S. Y., Jiang, H., Wu, Y., Jun, K., Wu, D., Kano, M. & Shin, H.
S. Deficient long-term synaptic depression in the rostral cerebellum correlated
with impaired motor learning in phospholipase Cβ4 mutant mice. Eur. J. Neurosci. 13, 1945-1954 (2001).
Maejima, T., Hashimoto, K., Yoshida, T., Aiba, A. & Kano, M. Presynaptic
inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid
receptors. Neuron 31, 463-475 (2001).
Hashimoto, K., Ichikawa, R., Takechi, H.,
Inoue, Y., Aiba, A., Sakimura, K., Mishina, M., Hashikawa, T., Konnerth, A.,
Watanabe, M. & Kano, M. Roles of glutamate receptor δ2 subunit (GluRδ2) and metabotropic glutamate receptor subtype 1 (mGluR1)
in climbing fiber synapse elimination during postnatal cerebellar development. J. Neurosci. 21, 9701-9712 (2001).
McGee, A. W., Topinka, J. R., Hashimoto, K., Petralia, R. S., Kakizawa,
S., Kauer, F., Aguilera-Moreno, A., Wenthold, R. J., Kano, M. & Bredt,
D. S. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required
for development or function of parallel fiber synapses in cerebellum. J. Neurosci. 21, 3085-3091 (2001).
Miyata, M., Finch, E. A., Khiroug, L., Hashimoto, K., Hayasaka, S., Oda,
S. I., Inouye, M., Takagishi, Y., Augustine, G. J. & Kano, M. Local
calcium release in dendritic spines required for long-term synaptic depression.
Neuron 28, 233-244 (2000).
Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto,
R., Katsuki, M. & Aiba, A. mGluR1 in cerebellar Purkinje cells essential
for long-term depression, synapse elimination, and motor coordination.
Science 288, 1832-1835 (2000).
Miyata,
M., Okada, D., Hashimoto, K., Kano, M. & Ito, M.
Corticotropin-releasing factor plays a permissive role in cerebellar
long-term depression. Neuron 22, 763-775 (1999).
Hashimoto, K., Fukaya, M., Qiao, X., Sakimura, K., Watanabe, M. & Kano, M. Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J. Neurosci. 19, 6027-6036 (1999).
Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y.,
Okuyama, S., Sakagawa, T., Ogawa, S., Kawashima, N., Hori, S., Takimoto,
M., Wada, K. & Tanaka, K. Motor discoordination and increased susceptibility
to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10, 976-988 (1998).
Watanabe,
D., Inokawa, H., Hashimoto, K., Suzuki, N., Kano, M., Shigemoto, R.,
Hirano, T., Toyama, K., Kaneko, S., Yokoi, M., Moriyoshi, K., Suzuki,
M., Kobayashi, K., Nagatsu, T., Kreitman, R. J., Pastan, I. &
Nakanishi, S. Ablation of cerebellar Golgi cells disrupts synaptic
integration involving GABA inhibition and NMDA receptor activation in
motor coordination. Cell 95, 17-27 (1998).
Kano, M., Hashimoto, K., Watanabe, M.,
Kurihara, H., Offermanns, S., Jiang, H., Wu, Y., Jun, K., Shin, H. S., Inoue,
Y., Simon, M. I. & Wu, D. Phospholipase cβ4 is specifically involved in climbing fiber synapse elimination in the
developing cerebellum. Proc. Natl. Acad. Sci. USA 95,
15724-15729 (1998).
Hashimoto, K. & Kano, M. Presynaptic origin of paired-pulse depression
at climbing fibre- Purkinje cell synapses in the rat cerebellum. J. Physiol. 506, 391-405 (1998).
Offermanns, S., Hashimoto, K.（共同第一著者） , Watanabe, M., Sun, W., Kurihara, H., Thompson, R. F., Inoue, Y.,
Kano, M. & Simon, M. I. Impaired motor coordination and persistent multiple
climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq. Proc. Natl. Acad. Sci. USA 94, 14089-14094 (1997).
Kurihara, H., Hashimoto, K., Kano, M., Takayama, C., Sakimura, K., Mishina,
M., Inoue, Y. & Watanabe, M. Impaired parallel fiber-->Purkinje
cell synapse stabilization during cerebellar development of mutant mice
lacking the glutamate receptor d2 subunit. J. Neurosci. 17, 9613-9623 (1997).
Kano, M., Hashimoto, K., Kurihara, H., Watanabe, M., Inoue, Y., Aiba, A.
& Tonegawa, S. Persistent multiple climbing fiber innervation of cerebellar
Purkinje cells in mice lacking mGluR1. Neuron 18, 71-79 (1997).
Miyata,
M., Hashimoto, K., Kano, M. & Ito, M. Corticotropin releasing
factor (CRF) induces long-lasting depression of parallel fiber to
Purkinje cell synaptic transmission in rat cerebellum. J. Physiol. (Paris) 90, 419-420 (1996).
Chen, C., Kano, M., Abeliovich, A., Chen, L., Bao, S., Kim, J. J., Hashimoto,
K., Thompson, R. F. & Tonegawa, S. Impaired motor coordination correlates
with persistent multiple climbing fiber innervation in PKCγ mutant mice.
Cell 83, 1233-1242 (1995).
Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara,
H., Watanabe, M., Inoue, Y. & Tonegawa, S. Impaired synapse elimination during cerebellar development
in PKCγ mutant mice. Cell 83, 1223-1231 (1995).
英文総説
Hashimoto, K. Mechanisms for the resonant property in rodent neurons. Neurosci. Res, 156, 5-13 (2020) doi: 10.1016/j.neures.2019.12.013.
Hashimoto, K. & Kano, M. Synapse elimination in the developing cerebellum.
Cellular and Molecular Life Sciences, 70, 4667-4680 (2013).
Kano, M., Nakayama, H., Hashimoto, K., Kitamura, K., Sakimura, K., Watanabe, M. Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development. J. Physiol.. 591, 3151-3158 (2013)
Kano M, Hashimoto K. Activity-Dependent Maturation of Climbing Fiber to
Purkinje Cell Synapses during Postnatal Cerebellar Development. Cerebellum. 11, 449-450 (2012)
Yamazaki, M., Fukaya, M., Hashimoto, K., Yamasaki, M., Tsujita, M.,
Itakura, M., Abe, M., Natsume, R., Takahashi, M., Kano, M., Sakimura, K.
& Watanabe, M. TARPs γ-2 and γ-7 are essential for AMPA receptor
expression in the cerebellum. Eur. J. Neurosci. 31, 2204-2220 (2010)
Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M. & Kano, M. Influence of parallel fiber-purkinje cell synapse formation on postnatal development of climbing fiber-purkinje cell synapses in the cerebellum. Neuroscience. 162, 601-611 (2009).
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